Women with rare cancer mutations likely to develop interval breast cancers

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WASHINGTON: According to a recent study, the presence of common breast cancer mutations are not only indicative of increased breast cancer risk, but certain rare mutations are also indicative of increased risk of interval breast cancers and death.

The study was published in Cancer Research, a journal of the American Association for Cancer Research.

“It is not enough just to know which markers can predict an increase in breast cancer risk. We also need to know which biomarkers can identify women with increased risk of aggressive interval cancers that are not usually detected during routine mammography screening,” said senior study author Jingmei Li.

Interval breast cancers are detected between mammography screenings; these cancers are often aggressive and have a poor prognosis. “About 20 per cent of women who partake in routine mammography screening will be diagnosed with interval breast cancer. More sensitive methods to predict and detect these lethal cancers are sorely needed,” explained Li.

Li and colleagues analysed data from over 5,000 breast cancer patients diagnosed between 2001 and 2008 through the Stockholm-Gotland Regional Breast Cancer quality register. The researchers studied associations with tumor characteristics and survival outcomes for patients with rare protein-truncating variants (PTVs) in 31 cancer predisposition genes, including BRCA1/2.

Additionally, the researchers developed a polygenic risk score (PRS) through the weighted sum of all known common breast cancer variants, which was also correlated with tumor characteristics and overall survival.

Since interval cancers are not identified through routine mammography screenings, Li and colleagues analysed the mode of detection for cancers driven by rare PTVs or common variants. A proportion of interval cancers may include tumors that were missed from routine mammography. Because dense tissue is one of the main reasons for masked tumors, women were stratified into risk categories based on percent breast density.

Out of the 5,099 breast cancer patients analyzed, 597 carried PTVs. These patients were younger, had more aggressive tumor phenotypes, and had 1.65 times the risk of death from breast cancer compared to those who did not carry PTVs. After excluding 92 women that carried mutations to BRCA1/2 from this cohort, women with PTVs had 1.76 times the risk of death from breast cancer compared to those without PTVs.

Analysis of 5,077 women who did not carry mutations to BRCA1/2 revealed that a higher PRS was associated with less aggressive tumor characteristics. Notably, no significant survival differences were associated with increases in PRS. (ANI)